Trejo-Acuña JR, González GM, Guzmán-Herrera S, López ZBE

Language: Spanish
References: 9
Page: 30-33
PDF size: 280.98 Kb.

ABSTRACT

Senear-Usher syndrome (also called pemphigus seborrheic or pemphigus erythematosus) is a localized form of pemphigus foliaceus. Epidemiological data are limited, as few cases have been reported in the literature. In superficial pemphigus, the pathogenic autoantibodies are generally of the IgG4 subclass, and are directed against the amino-terminal domain of desmoglein 1, a 160 kDa desmosomal cadherin, thus triggering the characteristic acantholysis of these entities. The lesions are located in typically seborrheic and sun-exposed areas. They consist of erythematous-scaly plaques, with an occasional positive Nikolsky sign. Diagnosis is made by histopathological study, with the finding of subcorneal blisters and acantholytic cells. First-line treatment is based on high-potency steroids. The prognosis is variable.

REFERENCES

1. Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS et al. Pemphigus. Nat Rev Dis Primers. 2017; 3: 17026. doi: 10.1038/nrdp.2017.26.

2. Yan L, Wang JM, Zeng K. Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis. Br J Dermatol. 2012; 167: 768-777. doi: 10.1111/j.1365-2133.2012.11040.x.

3. Vega-Memije ME, Sáez de Ocariz-Gutiérrez MM, Cortés-Franco R, Domínguez-Soto L, Granados-Arriola J. Análisis de HLA-DR en pacientes mexicanos con pénfigo. Gac Med Mex. 2001; 137: 535-540.

4. Stanley JR, Amagai M. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med. 2006; 355: 1800-1810. doi: 10.1056/NEJMra061111.

5. España A, Diaz LA, Mascaró JM Jr, Giudice GJ, Fairley JA, Till GO et al. Mechanisms of acantholysis in pemphigus foliaceus. Clin Immunol Immunopathol. 1997; 85: 83-89. doi: 10.1006/clin.1997.4407.

6. Kirk JA, Culton DA, Diaz LA. Diagnosis and clinical features of pemphigus foliaceus. Dermatol Clin. 2011; 29: 405-412.

7. Amagai M. Cap. 30: Pemphigus. In: Amagai M, Bolognia JL, Jorizzo JL, Schaffer JV. Dermatology. 3rd ed. Philadelphia: Elsevier; 2012. pp. 461-474.

8. Singh S. Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. Indian J Dermatol Venereol Leprol. 2011; 77: 456-469. doi: 10.4103/0378-6323.82400.

9. Atzmony L, Hodak E, Gdalevich M, Rosenbaum O, Mimouni D. Treatment of pemphigus vulgaris and pemphigus foliaceus: a systematic review and meta-analysis. Am J Clin Dermatol. 2014; 15: 503-515.