García-García GM, Pascual-Pérez MJ, Cimadevilla-Fernández I, López-Moreno AM, Aranda-López CA

Language: Spanish
References: 12
Page: 1096-1099
PDF size: 213.23 Kb.

ABSTRACT

Background: Metronidazole is an active antibiotic against anaerobic and protozoal germs. It has been associated with gastrointestinal or genitourinary adverse effects, although they have also been described in nervous system, which are infrequent and generally reversible after discontinuation of the drug.
Clinical case: A 70-year-old male patient who presented symptoms compatible with cerebellar involvement after metronidazole administration for one month, with disappearance of symptoms and neuroimaging findings after discontinuation of the drug. On the other hand, transient apical dyskinesia was diagnosed based on the electrocardiographic and echocardiographic abnormalities triggered by the acute stress caused by the neurological involvement.
Conclusions: Neurotoxicity due to metronidazole is a rare adverse effect that may produce this antibiotic; clinical and radiological relieve when the drug is suspended is characteristic. Our case was associated to takotsubo myocardiopathy due to the stress provoked by the neurological disease.

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