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Federación Mexicana de Ginecología y Obstetricia, A.C.

2023, Number 05

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Ginecol Obstet Mex 2023; 91 (05)

Granular cell tumor of vulva: a rare benign genital tumor

Gómez-Ortiz C, Gallardo-Martínez J, Pineda-Mateo M, Rodríguez-Jiménez I, Machuca-Aguado J, Pantoja-Garrido M

Language: Spanish
References: 11
Page: 366-370
PDF size: 230.11 Kb.


ABSTRACT

Background: Granular cell tumor of the vulva is rare and neurogenic in origin. It mainly affects women between 60 and 70 years of age and is more frequent in black women.
Clinical case: A 63-year-old woman with a painless, non-pruritic, growing vulvar lesion. Examination revealed a 2.5 cm excrescent lesion in the upper region of the left labium majus, hard, vascularized and infiltrated to a depth of 2 cm. No suspicious lymph nodes were palpated. After the biopsy report, suggestive of granular cell tumor, complete excision was performed, with free margins. The immunohistochemical study was positive for CD68, S100 and TFE3 which confirming the diagnosis. Since the proliferative index (Ki67) was less than 5% and the surgical margins were clear, adjuvant treatment was not required. The patient remains in follow-up with no signs of recurrence.
Conclusion: Although granular cell tumors of the vulva are rare and almost always benign, they should be included in the differential diagnosis of a vulvar tumor. Immunohistochemistry is the most useful tool for accurate diagnosis and their treatment of choice is wide local excision because of their tendency for local recurrence.


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