medigraphic.com
SPANISH

Revista del Centro Dermatológico Pascua

ISSN 1405-1710 (Print)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2023, Number 3

<< Back Next >>

Rev Cent Dermatol Pascua 2023; 32 (3)

Spitz Nevus

Alcalá-Pérez D, González-González M, Angulo-Rodríguez A, Alvarado-Benítez AM
Full text How to cite this article 10.35366/117100

DOI

DOI: 10.35366/117100
URL: https://dx.doi.org/10.35366/117100

Language: Spanish
References: 13
Page: 100-104
PDF size: 291.70 Kb.


Key words:

Spitz nevus, melanocytes, neoplasm, malignant potential.

ABSTRACT

Spitz nevus is a melanocytic neoformation derived from epithelioid or spindle-shaped melanocytes that usually develops during childhood. Although it is considered a benign neoplasm, its malignant potential towards melanoma remains uncertain, hence prompt diagnosis and treatment must be carried out. We present the case of a 9-year-old male patient, who attended the external consultation due to a neoplasm in the proximal third of his right forearm, which bled easily after being traumatized. The lesion was shaved and sent to our Dermatopathology Service with a suspected diagnosis of pyogenic granuloma. The histopathological report showed a Spitz nevus, requiring a surgical procedure for complete removal.


REFERENCES

  1. Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A. Spitz nevus and other spitzoid tumors in children - Part 1: clinical, histopathologic, and immunohistochemical features. Actas Dermosifiliogr (Engl Ed). 2020; 111: 7-19. doi: 10.1016/j.ad.2019.02.011.

  2. Brown A, Sawyer JD, Neumeister MW. Spitz nevus: review and update. Clin Plast Surg. 2021; 48: 677-686. doi: 10.1016/j.cps.2021.06.002.

  3. Dika E, Ravaioli GM, Fanti PA, Neri I, Patrizi A. Spitz nevi and other spitzoid neoplasms in children: overview of incidence data and diagnostic criteria. Pediatr Dermatol. 2017; 34: 25-32. doi: 10.1111/pde.13025.

  4. Neri I, Dika E, Ravaioli GM, Patrizi A. Spitz nevi: defining features and management in children. G Ital Dermatol Venereol. 2014; 149: 675-682.

  5. Quan VL, Panah E, Zhang B, Shi K, Mohan LS, Gerami P. The role of gene fusions in melanocytic neoplasms. J Cutan Pathol. 2019; 46: 878-887. doi: 10.1111/cup.13521.

  6. Wiesner T, Kutzner H, Cerroni L, Mihm MC Jr, Busam KJ, Murali R. Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy. Pathology. 2016; 48: 113-131. doi: 10.1016/j.pathol.2015.12.007.

  7. Dal Pozzo CA, Cappellesso R. The morpho-molecular landscape of Spitz neoplasms. Int J Mol Sci. 2022; 23: 4211. doi: 10.3390/ijms23084211.

  8. Menezes FD, Mooi WJ. Spitz tumors of the skin. Surg Pathol Clin. 2017; 10: 281-298. doi: 10.1016/j.path.2017.01.004.

  9. Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A. Differential diagnosis of Spitzoid melanocytic neoplasms. J Eur Acad Dermatol Venereol. 2016; 30: 1269-1277. doi: 10.1111/jdv.13665.

  10. Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P et al. Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society. Br J Dermatol. 2017; 177: 645-655. doi: 10.1111/bjd.15339.

  11. Calonje E, Brenn T, Lazar A, McKee PH. McKee's pathology of the skin: with clinical correlations. 4th ed. ed. Elsevier/Saunders; 2012; pp. 1178-1185.

  12. Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A. Spitz nevus and other spitzoid tumors in children. Part 2: cytogenetic and molecular features. Prognosis and treatment. Actas Dermosifiliogr (Engl Ed). 2020; 111: 20-25. doi: 10.1016/j.ad.2019.02.010.

  13. Ferrara G, Gianotti R, Cavicchini S, Salviato T, Zalaudek I, Argenziano G. Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. Dermatol Clin. 2013; 31: 589-598. doi: 10.1016/j.det.2013.06.012.




Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Table 1

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Cent Dermatol Pascua. 2023;32