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Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología

2025, Number 5

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Acta Ortop Mex 2025; 39 (5)

Persistent myxoinflammatory fibroblastic sarcoma: an unusual case report and literature review

Ugalde-Fuentes J, Alcántara-Ramos G

Language: Spanish
References: 17
Page: 313-318
PDF size: 406.98 Kb.


ABSTRACT

Introduction: myxoinflammatory fibroblastic sarcoma is a rare type of sarcoma characterized by the abnormal growth of mesenchymal tissue. It is known for its locally aggressive behavior, high recurrence rate, and potential for metastasis. Clinically, it typically presents as a superficial, painless subcutaneous mass, although it may sometimes cause pain and restricted movement. Histologically, comprises spindle cells with myxoid stroma and large atypical cells with marked nuclear pleomorphism, similar to Reed-Sternberg cells. Case presentation: an 83-year-old woman presented with a lesion on the anterior region of her left leg. A comprehensive study protocol for a musculoskeletal tumor was initiated, followed by an incisional biopsy for histological and immunohistochemical analysis, which led to the diagnosis of myxoinflammatory fibroblastic sarcoma. The tumor was surgically resected, and the intraoperative and final report indicated negative surgical margins. Results: the patient experienced a favorable recovery and regained full mobility. Despite initial treatment and recovery, signs of local persistence were observed during follow-up four months later. The patient opted not to pursue the recommended treatment, choosing instead to continue monitoring the lesion. Conclusions: this case underscores the importance of including myxoinflammatory fibroblastic sarcoma in the differential diagnosis of musculoskeletal lesions and highlights the need for multidisciplinary collaboration for accurate diagnosis and effective treatment.


REFERENCES

  1. Lucas DR. Myxoinflammatory fibroblastic sarcoma: Review and update. Arch Pathol Lab Med. 2017; 141(11): 1503-7. Available in: http://dx.doi.org/10.5858/arpa.2017-0219-ra

  2. Sly M, Clark K, Wichelt E, Yehia S, Craib S, Alechko S, et al. Myxoinflammatory fibroblastic soft tissue sarcoma with multiple recurrences, case report of uncommon tumor with challenging diagnosis and review of the literature. SM J Sarcoma Res. 2021; 7(4): 1-4. Available in: https://www.jsmcentral.org/article-info/Myxoinflammatory-Fibroblastic-Soft-Tissue-Sarcoma-with-Multiple-Recurrences-Case-Report-of-Uncommon-Tumor-with-Challenging-Diagnosis-and-Review-of-the-Literature

  3. Jagadesh N, Miller DH, Schenk W, Attia S, Sherman CE, Cortese C, et al. Recurrent myxoinflammatory fibroblastic sarcoma: a case report. Clin Case Rep. 2017; 5(6): 871-5. Available in: http://dx.doi.org/10.1002/ccr3.949

  4. Kato M, Tanaka T, Ohno T. Myxoinflammatory fibroblastic sarcoma: A radiographical, pathological, and immunohistochemical report of rare malignancy. Case Rep Orthop. 2015; 2015: 1-5. Available in: http://dx.doi.org/10.1155/2015/620923

  5. Suster D, Michal M, Huang H, Ronen S, Springborn S, Debiec-Rychter M, et al. Myxoinflammatory fibroblastic sarcoma: an immunohistochemical and molecular genetic study of 73 cases. Mod Pathol. 2020; 33(12): 2520-33. Available in: http://dx.doi.org/10.1038/s41379-020-0580-6

  6. Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica. 2021; 113(2): 70-84. doi: 10.32074/1591-951X-213.

  7. Wu H, Laskin WB. Myxoinflammatory fibroblastic sarcoma. Surg Pathol Clin. 2024; 17(1): 83-96.

  8. Nishio J, Nakayama S, Aoki M. Recent advances in the diagnosis, pathogenesis, and management of myxoinflammatory fibroblastic sarcoma. Int J Mol Sci. 2024; 25(2): 1127. doi: 10.3390/ijms25021127.

  9. Srivastava P, Husain N, Neyaz A, Gupta V. Aggressive myxoinflammatory fibroblastic sarcoma with multiple site metastases. BMJ Case Rep. 2018; 2018: bcr2018224259. doi: 10.1136/bcr-2018-224259.

  10. Hassanein AM, Atkinson SP, Al-Quran SZ, Jain SM, Reith JD. Acral myxoinflammatory fibroblastic sarcomas: are they all low-grade neoplasms? J Cutan Pathol. 2008; 35(2): 186-191. doi: 10.1111/j.1600-0560.2007.00789.x.

  11. Kumar R, Lefkowitz RA, Neto AD. Myxoinflammatory fibroblastic sarcoma: clinical, imaging, management and outcome in 29 patients. J Comput Assist Tomogr. 2017; 41(1): 104-115. doi: 10.1097/RCT.0000000000000490.

  12. Martínez-Trufero J, Cruz Jurado J, Gómez-Mateo MC, Bernabeu D, Floría LJ, Lavernia J, et al. Uncommon and peculiar soft tissue sarcomas: Multidisciplinary review and practical recommendations for diagnosis and treatment. Spanish group for Sarcoma research (GEIS - GROUP). Part I. Cancer Treat Rev. 2021; 99: 102259. doi: 10.1016/j.ctrv.2021.102259.

  13. Baheti AD, Tirumani SH, Rosenthal MH, Howard SA, Shinagare AB, Ramaiya NH, et al. Myxoid soft-tissue neoplasms: comprehensive update of the taxonomy and MRI features. AJR Am J Roentgenol. 2015; 204(2): 374-85. doi: 10.2214/AJR.14.12888.

  14. Alhumaidan MI, Bin Makhashen M, Bassas AF, Mater ME, Alsufayan FA, Alfaqeeh FA. Myxoinflammatory fibroblastic sarcoma of the hand. plastic and reconstructive surgery. Global Open. 2023; 11(4): e4934. doi: 10.1097/gox.0000000000004934.

  15. Boran C, Kilitci A, Ahsen H, Y?lmaz F. The first case of myxoinflammatory fibroblastic sarcoma affecting the maxillary bone. Int J Health Sci (Qassim). 2022; 16(2): 37-9.

  16. Laskin WB, Fetsch JF, Miettinen M. Myxoinflammatory fibroblastic sarcoma: a clinicopathologic analysis of 104 cases, with emphasis on predictors of outcome. Am J Surg Pathol. 2014; 38(1): 1-12. doi: 10.1097/PAS.0b013e31829f3d85.

  17. Sakaki M, Hirokawa M, Wakatsuki S, Sano T, Endo K, Fujii Y, et al. Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature. Virchows Arch. 2003; 442(1): 25-30. doi: 10.1007/s00428-002-0723-9.




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