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2026, Number 1

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Invest ISSSTE 2026; 1 (1)

Interaction between iron and the human immunodeficiency virus: an analysis of its influence on pathogenesis and immune response

Rodríguez-Hernández SA, García-Oropesa EM, Hernández-Martínez JC, Flores-Gómez JF, Gaspar-Coronado JA, Nolasco-Quiroga M, Rosas-Díaz M

Language: Spanish
References: 17
Page: 38-41
PDF size: 661.22 Kb.


ABSTRACT

Human immunodeficiency virus (HIV) infection disrupts iron metabolism, thereby influencing disease progression and the host immune response. This article reviews the current evidence on how iron overload or deficiency affects HIV pathogenesis. Iron acts as a cofactor for key enzymes in viral replication (ribonucleotide reductase) and for NF-κB activation via reactive oxygen species (ROS). Iron overload increases viral transcription, impairs the function of macrophage and T-lymphocytes, and raises the risk of opportunistic infections. Conversely, deficiency resulting from chronic bleeding, malabsorption, or elevated hepcidin causes iron-deficiency anemia, blunts immune responses, and is associated with higher mortality. Maintaining iron within physiological ranges should therefore be a therapeutic goal in HIV infection.


REFERENCES

  1. GBD 2021 HIV Collaborators. Global, regional, and nationalburden of HIV/AIDS, 1990-2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of DiseaseStudy 2021. Lancet HIV. 2024;11(12):e807-e82

  2. Available in:https://doi.org/10.1016/S2352-3018(24)00093-22. Gordeuk VR, Onojobi G, Schneider MF, Dawkins FW, DelapenhaR, Voloshin Y, von Wyl V, Bacon M, Minkoff H, Levine A,Cohen M, Greenblatt RM. The association of serum ferritinand transferrin receptor concentrations with mortality inwomen with human immunodeficiency virus infection.Haematologica. 2006;91(6):739-743.

  3. Moreno CJ, Delgado LA, Castillo MZ. Relación de los nivelesde ferritina sérica con infecciones oportunistas en pacientesVIH/SIDA. Unidad de infectología. Hospital Universitario “Dr.Ángel Larralde”. Estado Carabobo, junio 2010-2012. Bol VenezInfectol. 2015;26(1):5-13.

  4. Banjoko SO, Oseni FA, Togun RA, Onayemi O, Emma-OkonBO, Fakunle JB. Iron status in HIV-1 infection: implications indisease pathology. BMC Clin Pathol. 2012;12:26. Available in:https://doi.org/10.1186/1472-6890-12-26.

  5. Kharb S, Kumawat M, Lallar M, Ghalaut PS, Nanda S. Serumiron, Folate, Ferritin and CD4 Count in HIV SeropositiveWomen. Indian J Clin Biochem. 2017;32(1):95-98. Available in:https://doi.org/10.1007/s12291-016-0571-z

  6. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism.Annu Rev Med. 2011;62:347-60. Available in: https://doi.org/10.1146/annurev-med-050109-142444

  7. Przybyszewska J, Zekanowska E. The role of hepcidin,ferroportin, HCP1, and DMT1 protein in iron absorption in thehuman digestive tract. Prz Gastroenterol. 2014;9(4):208-213.Available in: https://doi.org/10.5114/pg.2014.45102

  8. Corrales-Agudelo V, Parra-Sosa BE, Burgos-Herrera LC.Proteínas relacionadas con el metabolismo del hierro corporal.Perspect Nut Hum. 2016;18(1):95-116. Disponible en: https://doi.org/10.17533/udea.penh.v18n1a08

  9. Drakesmith H, Prentice A. Viral infection and iron metabolism.Nat Rev Microbiol. 2008;6(7):541-552. Available in: https://doi.org/10.1038/nrmicro1930.

  10. Yun S, Vincelette ND. Update on iron metabolism andmolecular perspective of common genetic and acquireddisorder, hemochromatosis. Crit Rev Oncol Hematol.2015;95(1):12-25. Available in: https://doi.org/10.1016/j.critrevonc.2015.02.006

  11. Kowdley KV. Iron, hemochromatosis, and hepatocellularcarcinoma. Gastroenterology. 2004;127(5 Suppl 1):S79-86.Available in: https://doi.org/10.1016/j.gastro.2004.09.019

  12. Muñoz M, García-Erce JA, Remacha ÁF. Disorders of ironmetabolism. Part II: iron deficiency and iron overload. JClin Pathol. 2011;64(4):287-296. Available in: https://doi.org/10.1136/jcp.2010.086991

  13. Silva B, Faustino P. An overview of molecular basis of ironmetabolism regulation and the associated pathologies.Biochim Biophys Acta. 2015;1852(7):1347-1359. Available in:https://doi.org/10.1016/j.bbadis.2015.03.011

  14. San-Miguel A, Alonso N, Calvo B, Iglesias R, San-Miguel R, Martín-Gil FJ. DiagnÓstico molecular del gen HFE de la hemochromatosishereditarian. Gac Med Bilbao. 2008; 105: 85-93.

  15. Ben Haij N, Planès R, Leghmari K, Serrero M, Delobel P,Izopet J, et al. HIV-1 Tat protein induces production ofproinflammatory cytokines by human dendritic cells andmonocytes/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-κB pathway. PLoS One.2015;10(6):e0129425. Available in: https://doi.org/10.1371/journal.pone.0129425

  16. Del Pino García J. Interacción funcional de la eIF2α quinasaGCN2 con el virus de la inmunodeficiencia humana VIH-1 [Tesisdoctoral, Universidad Autónoma de Madrid]. Repositorioinstitucional UAM. 2008. Disponible en: https://repositorio.uam.es/handle/10486/61373

  17. Cordeiro N, Taroco R. Retrovirus y VIH. En: Algorta G, Amorin B,Arbiza JR, et al. Uruguay. Universidad de la república. Facultadde Medicina. Instituto de Higiene. Temas de bacteriología yvirología médica. Montevideo: IH, 2008, pp. 449-476.




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