González-Gutiérrez AM, Ortiz-Muñiz AR, García-Rodríguez MC, Cortés-Barberena E

Language: Spanish
References: 76
Page: 70-81
PDF size: 612.95 Kb.

ABSTRACT

The purpose of this review is to present relevant information regarding the main histone modifications that intervene in the detection and repair of damaged genetic material (known as DNA damage response, (DDR)). Genomic integrity is vital for cellular well-being. Cells have developed review and maintenance systems to ensure adequate protection of genetic information. The nuclear genome is organized into a complex of histones and deoxyribonucleic acid (DNA) called nucleosome; the adaptability of this structure allows access to the proteins necessary to carry out biological processes such as transcription, duplication, and DNA repair. Histone proteins can present chemical modifications that, alone or in combination with others, provide specific biological results; this is known as the 'histone code'. In recent years, the study of post-translational modifications (PTMs) in histone proteins and their connection with the network of pathways DDR has increased.

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