Ramírez GJY, Reyes FJE, Berrezueta CNC

Language: Spanish
References: 10
Page: 207-210
PDF size: 227.57 Kb.

ABSTRACT

Porokeratosis is a rare group of skin disorders characterized by abnormal keratinization. Risk factors include genetic alterations, infections, and ultraviolet radiation exposure, among others. Several clinical variants have been described, including disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis, linear porokeratosis, follicular porokeratosis, and porokeratoma. Diagnosis is established through clinicopathological correlation, supported by complementary tools like dermoscopy and reflectance confocal microscopy.
We report the case of a female patient with a solitary lesion on her palm, which had been present for five years. This case is notable for its unusual location, hypokeratotic morphology, and isolated clinical presentation, making it a diagnostic challenge rarely documented in dermatologic literature.

REFERENCES

1. Kostopoulos-Kanitakis KA y Kanitakis J, Porokeratoses: anupdate on pathogenesis and treatment, Int J Dermatol 2025;64(1):62-71. doi: 10.1111/ijd.17411. Epub 11 de agosto de 2024.pmid: 39129190; pmcid: pmc11685060.

2. Yang J, Du YQ, Fang XY, Li B, Xi ZQ y Feng WL, Linear porokeratosisof the foot with dermoscopic manifestations: a case report,World J Clin Cases 2022; 10(31):11585-9. doi: 10.12998/wjcc.v10.i31.11585. pmid: 36387824; pmcid: pmc9649560.

3. Paolino G, Di Nicola MR, Yarygina M, Mattozzi C, QuarantaE, Bianchi VG, Donati M y Mercuri SR, Exclusive and solitaryfacial porokeratosis: pathogenesis and literature reappraisalof a rare entity, Case Rep Dermatol 2023; 15(1):147-51. doi:10.1159/000530936. pmid: 37899946; pmcid: pmc10601618.

4. Anderska A, Kaczmarska-Such A, Mazur E y Reich A, Porokeratoses:a rare group of dermatoses, Medicina (Kaunas) 2024;60(11):1876. doi: 10.3390/medicina60111876. pmid: 39597061;pmcid: pmc11596848.

5. Pietkiewicz P, Korecka K, Salwowska N, Kohut I, Adhikari A,Bowszyc-Dmochowska M, Pogorzelska-Antkowiak A y Navarrete-Dechent C, Porokeratoses: a comprehensive reviewon the genetics and metabolomics, imaging methods andmanagement of common clinical variants, Metabolites 2023;13(12):1176. doi: 10.3390/metabo13121176. pmid: 38132857;pmcid: pmc10744643.

6. Zaar O, Polesie S, Navarrete-Dechent C, Errichetti E, Akay BN,Jaimes J, Cabo H, Cohen Sabban E y Paoli J, Dermoscopy ofporokeratosis: results from a multicentre study of the InternationalDermoscopy Society, jeadv 2021; 35(10):2091-6. doi:https://doi.org/10.1111/jdv.17439.

7. Batalla A y De la Torre C, Circumscribed plantar hypokeratosisresponding to topical calcipotriol, J Dermatol Case Rep 2013;7(4):129-31. doi: 10.3315/jdcr.2013.1155. pmid: 24421867; pmcid:pmc3888783.

8. Kim JH, Shim J, Park SW, Shin HT, Park JH, Lee DY, A caseof solitary porokeratosis mimicking circumscribed palmarhypokeratosis, Ann Dermatol 2015; 27(2):233-4. doi: 10.5021/ad.2015.27.2.233. Epub 24 de marzo de 2015. pmid: 25834375;pmcid: pmc4377425.

9. Das A, Vasudevan B y Talwar A, Porokeratosis: an enigma beginningto unravel, Indian J Dermatol Venereol Leprol 2022;88(3):291-9. doi: 10.25259/ijdvl_806_20 pmid: 34877845.

10. Jägle S, Juratli HA, Hickman G, Süssmuth K, Boente MC, KoppJ, Kirchmeier P, Zimmer A, Happle R, Bourrat E, Hamm H y FischerJ, Porokeratosis plantaris, palmaris et disseminata causedby congenital pathogenic variants in the mvd gene and lossof heterozygosity in affected skin, Acta Derm Venereol 2021;101(2):adv00397. doi: 10.2340/00015555-3753. pmid: 33491095;pmcid: pmc9366687.