medigraphic.com
SPANISH

Latin American Journal of Oral and Maxillofacial Surgery

ISSN 2992-7757 (Electronic)
Órgano de difusión de la Asociación Latinoamericana de Cirugía y Traumatología Bucomaxilofacial (ALACIBU)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2025, Number 4

<< Back Next >>

Lat Am J Oral Maxillofac Surg 2025; 5 (4)

Oral pyogenic granuloma as a manifestation of Klippel-Trénaunay syndrome: a literature review and case report

Vega GS, Espinoza OF, Torrealba MF, Contreras VL
Full text How to cite this article 10.35366/122830

DOI

DOI: 10.35366/122830
URL: https://dx.doi.org/10.35366/122830

Language: Spanish
References: 8
Page: 171-173
PDF size: 943.08 Kb.


Key words:

pyogenic granuloma, Klippel-Trénaunay syndrome, vascular malformations, oral manifestations.

ABSTRACT

Pyogenic granuloma is a common benign vascular lesion of the oral cavity, particularly on the gingiva, whose development is associated with local trauma, chronic irritants, hormonal changes, or certain medications. It is characterized by its rapid appearance, erythematous aspect, lobulated surface, and tendency to bleed. In contrast, Klippel-Trenaunay syndrome is a congenital disease that combines capillary, venous, and/or lymphatic malformations with hypertrophy of soft tissues and bone structures. The oral manifestation of this syndrome is uncommon, and the appearance of pyogenic granulomas in this context has been sparsely reported in the literature, which poses a diagnostic and therapeutic challenge. This article reviews the clinical, histopathological, pathophysiological, and genetic features of pyogenic granuloma and Klippel-Trenaunay syndrome, highlighting a possible pathogenic interaction between both conditions. This review provides the necessary theoretical framework for the subsequent presentation of a relevant clinical case.


REFERENCES

  1. Jafarzadeh H, Sanatkhani M, Mohtasham N. Oral pyogenic granuloma: a review. J Oral Sci. 2006; 48 (4): 167-175.

  2. Keppler-Noreuil KM, Rios JJ, Parker VE, et al. PIK3CA-related overgrowth spectrum (PROS): Diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015; 167A (2): 287-295.

  3. Castel P, Carmona FJ, Grego-Bessa J, et al. Somatic PIK3CA mutations as a cause of sporadic venous malformations in humans. Sci Transl Med. 2016; 8 (332): 332ra43.

  4. Brouillard P, Vikkula M. Genetic causes of vascular malformations. Hum Mol Genet. 2007; 16 (R2): R140-R149.

  5. Vahidnezhad H, Youssefian L, Uitto J. Molecular genetics of the PI3K-AKT pathway: Its impact on cutaneous and systemic vascular anomalies. J Invest Dermatol. 2016; 136 (2): 239-247.

  6. Greene AK, Alomari AI. Management of arteriovenous malformations. Clin Plast Surg. 2011; 38 (1): 95-106.

  7. Itkin M, Nadolski GJ. Vascular anomalies: classification, diagnosis, and management. Cardiovasc Diagn Ther. 2019; 9 (Suppl 1): S25-S38.

  8. Saghafi S, Amoueian S, Montazer M, Bostan R. Assessment of VEGF, CD-31 and Ki-67 expression in oral pyogenic granuloma: an immunohistochemical study. Iran J Basic Med Sci. 2011; 14 (2): 185-189.




Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Lat Am J Oral Maxillofac Surg. 2025;5