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2026, Number 1

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Cardiovasc Metab Sci 2026; 37 (1)

Brugada syndrome with type 2 pattern. Case report

Dervil-Arroyo CA, Torre-Gómez VA, Baños-González MA, Guzmán-Priego CG, Baeza-Flores GC

Language: English
References: 16
Page: 21-27
PDF size: 997.60 Kb.


ABSTRACT

Brugada syndrome is an inherited cardiac channelopathy that leads to malignant ventricular arrhythmias and sudden cardiac death, despite the absence of signs of structural heart disease. The syndrome’s characteristic electrocardiographic pattern is rare and may be the only clinical manifestation, which complicates identification. This syndrome accounts for between 4 and 12% of cases of sudden cardiac death and up to 20% in patients with structurally normal hearts. It predominantly affects men, with a frequency of eight to 10 times compared to women, and an estimated prevalence of one to five cases per 10,000 individuals. The SCN5A gene is the most associated mutation, identified in 11 to 28% of cases. Syncope is the most relevant clinical sign, although it is not always present. Currently, diagnosis and risk stratification remain a clinical challenge due to the lack of consensus on reliable prognostic markers. Studies such as FINGER and PRELUDE have questioned the usefulness of inducibility in electrophysiological studies as a prognostic criterion, limiting its applicability in clinical practice. This report describes the case of a young asymptomatic male patient who has no relevant personal or family medical history and presents an electrocardiographic pattern consistent with Brugada syndrome. This finding poses a significant clinical challenge regarding risk assessment, highlighting the need for more precise criteria for the management of these patients.


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