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2026, Number 1

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Rev Mex Pediatr 2026; 93 (1)

Stevens-Johnson syndrome induced by trimethoprim-sulfamethoxazole

Pachicano-Leal JLT, Liñán-Vázquez A

Language: Spanish
References: 19
Page: 32-35
PDF size: 1365.29 Kb.


ABSTRACT

Introduction: the spectrum of Stevens-Johnson syndrome (SJS) - toxic epidermal necrolysis - constitutes a serious allergic dermatological condition, frequently associated with commonly prescribed medications. Its timely recognition and treatment are essential to improve prognosis. Objective: to describe the management and evolution of a pediatric patient with SJS. Case description: a 2-year-10-month-old female patient was admitted to the emergency department after ingesting trimethoprim/sulfamethoxazole (TMP/SMZ) with fever, necrotic-hemorrhagic ulcers on her lips, and skin involvement of her extremities. She received supportive treatment and showed favorable clinical evolution in less than a week. Conclusion: TMP/SMZ can be associated with severe drug eruptions; in the presence of a prodromal condition with mucocutaneous involvement, SJS should be suspected.


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