2026, Number 2
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Rev Fac Med UNAM 2026; 69 (2)
Common Vulvovaginal Infections in Primary Care: Bacterial Vaginosis, Candidiasis, and Trichomoniasis
Sánchez-Vega JT, Morales-Galicia AE, Sánchez-Suir DK, Sánchez-Aguilar JH, González-Vences JE, González-Aguirre D, Hernández-Larrainzar MA, de Villa-Hidalgo MG, Vega-Zavala AO, Figueroa-Fernández LA, Rincón-Sánchez MN, Ortiz-Pinzón BY, Vázquez-Cervantes AG
Language: Spanish
References: 49
Page: 8-22
PDF size: 366.10 Kb.
ABSTRACT
Vaginal infections are among the most prevalent conditions
affecting women of all ages, particularly those of reproductive
age and pregnant women. As a result, they constitute one of
the most common reasons for gynecological consultations
in primary care. This article reviews the main infectious etiologies—
Gardnerella vaginalis, Candida spp., and
Trichomonas
vaginalis—addressing their microbiological characteristics,
epidemiology, pathophysiology, risk factors, clinical manifestations,
diagnosis, differential diagnosis, complications,
and treatment. Bacterial vaginosis, primarily caused by G.
vaginalis, represents a disruption of the vaginal microbiota,
whereas vulvovaginal candidiasis and trichomoniasis result
from fungal and protozoal infections, respectively. Given the
similarities in clinical presentation, this review highlights the
importance of a thorough evaluation to differentiate between
these etiologies. It also discusses updated therapeutic
recommendations, including the most effective treatment
regimens. Furthermore, the potential complications in both
pregnant and non-pregnant women are analyzed, emphasizing
the need for appropriate management to minimize the
impact on reproductive health. This review aims to provide
general practitioners with a comprehensive and up-to-date
guide for the diagnosis and management of vaginal infections,
ultimately improving the quality of medical care and
patient outcomes.
REFERENCES
Latarjet M, Liard R. Anatomía humana. Tomo 2. 5a ed.Ciudad de México: Médica Panamericana; 2018.
Dalley AF, Agur AMR. Moore anatomía con orientaciónclínica. 9a ed. Baltimore (MD): Wolters Kluwer; 2022.
Pawlina W. Histology: a text and atlas: with correlated celland molecular biology. 9th ed. Philadelphia (PA): WoltersKluwer; 2023.
Kierszenbaum AL, Tres LL. Histology and cell biology:an introduction to pathology. 5th ed. Philadelphia (PA):Elsevier; 2019.
Gartner LP, Hiatt JL. Gartner & Hiatt’s atlas and textof histology. 8th ed. Philadelphia (PA): Wolters Kluwer;2022.
Paulsen DF. Histology and cell biology: examination andboard review. 6th ed. New York (NY): McGraw-Hill Education;2021.
Chee WJY, Chew SY, Than LTL. Vaginal microbiotaand the potential of Lactobacillus derivatives in maintainingvaginal health. Microb Cell Fact. 2020;19(1):203.doi:10.1186/s12934-020-01464-4.
Holdcroft AM, Ireland DJ, Payne MS. The vaginal microbiomein health and disease—what role do common intimatehygiene practices play? Microorganisms. 2023;11(2):298.doi:10.3390/microorganisms11020298.
Sousa LGV, Pereira SA, Cerca N. Fighting polymicrobialbiofilms in bacterial vaginosis. Microb Biotechnol.2023;16(7):1423-1437. doi:10.1111/1751-7915.14217.
Morsli M, Gimenez E, Magnan C, Salipante F, HuberlantS, Letouzey V, et al. The association between lifestylefactors and the composition of the vaginal microbiota: areview. Eur J Clin Microbiol Infect Dis. 2024;43(10):1869-1881. doi:10.1007/s10096-024-04879-0.
Souza SV, Monteiro PB, Moura GA, Santos NO, FontaneziCTB, Gomes IA, et al. Vaginal microbiome andthe presence of Lactobacillus spp. as interferences infemale fertility: a review study. JBRA Assist Reprod.2023;27(3):496-506. doi:10.5935/1518-0557.20230018.
Konadu DG, Owusu-Ofori A, Yidana Z, Boadu F, IddrisuLF, Adu-Gyasi D, et al. Prevalence of vulvovaginal candidiasis,bacterial vaginosis and trichomoniasis in pregnantwomen attending antenatal clinic in the middle beltof Ghana. BMC Pregnancy Childbirth. 2019;19(1):341.doi:10.1186/s12884-019-2508-z.
Kairys N, Carlson K, Garg M. Gardnerella vaginalis. In:StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;2025 [citado 2025 Mar 11]. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK459350/
Tužil J, Filková B, Malina J, Kerestes J, Doležal T. Smokingin women with chronic vaginal discomfort is not associatedwith decreased abundance of Lactobacillus spp. butpromotes Mobiluncus and Gardnerella spp. overgrowth—secondary analysis of trial data including microbiome analysis.Ceska Gynekol. 2021;86(1):22-29.
Bradshaw CS, Sobel JD. Current treatment of bacterialvaginosis—limitations and need for innovation. J InfectDis. 2016;214(Suppl 1):S14-S20. doi:10.1093/infdis/jiw159.
Villarreal E, Benítez S, Vargas ER, Martínez L, GaliciaL, Escorcia V. Incidencia de infecciones cervicovaginalesdiagnosticadas por citología y no tratadas médicamente.Ginecol Obstet Mex. 2018;86(3):186-192.
Peebles K, Velloza J, Balkus JE, McClelland RS,Barnabas RV. High global burden and costs of bacterialvaginosis: a systematic review and meta-analysis.Sex Transm Dis. 2019;46(5):304-311. doi:10.1097/OLQ.0000000000000972.
Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A,Swidsinski S, Hale LP, et al. Adherent biofilms in bacterialvaginosis. Obstet Gynecol. 2005;106(5 Pt 1):1013-1023.doi:10.1097/01.AOG.0000183594.45524.d2.
Sánchez JT. Bacteriología médica de JT. 1a ed. Ciudad deMéxico: Amolca; 2024.
Machado D, Castro J, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, Cerca N. Bacterial vaginosis biofilms:challenges to current therapies and emerging solutions. FrontMicrobiol. 2016;6:1528. doi:10.3389/fmicb.2015.01528.
Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis:2001-2004 National Health and Nutrition ExaminationSurvey data. Obstet Gynecol. 2007;109(1):114-120.doi:10.1097/01.AOG.0000247627.84791.91.
Amsel R, Totten PA, Spiegel CA, Chen KC, EschenbachD, Holmes KK. Nonspecific vaginitis: diagnostic criteriaand microbial and epidemiologic associations. Am J Med.1983;74(1):14-22. doi:10.1016/0002-9343(83)91112-9.
Abou Chacra L, Fenollar F, Diop K. Bacterial vaginosis:what do we currently know? Front Cell Infect Microbiol.2021;11:672429. doi:10.3389/fcimb.2021.672429.
Bagga R, Arora P. Genital micro-organisms in pregnancy. FrontPublic Health. 2020;8:225. doi:10.3389/fpubh.2020.00225.
Hay P. Recurrent bacterial vaginosis. Curr Infect Dis Rep.2000;2(6):506-512. doi:10.1007/s11908-000-0066-3.
Fidel PL Jr. History and update on host defense againstvaginal candidiasis. Am J Reprod Immunol. 2007;57(1):2-12. doi:10.1111/j.1600-0897.2006.00450.x.
López MR, Méndez TLJ, Hernández HF, Castañón OR.Micología médica: procedimientos para el diagnósticode laboratorio. 1a ed. Ciudad de México: Trillas; 2012.
Achkar JM, Fries BC. Candida infections of the genitourinarytract. Clin Microbiol Rev. 2010;23(2):253-273.doi:10.1128/CMR.00076-09.
Benedict K, Lyman M, Jackson BR. Possible misdiagnosis,inappropriate empiric treatment, and opportunitiesfor increased diagnostic testing for patients with vulvovaginalcandidiasis—United States, 2018. PLoS One.2022;17(4):e0267866. doi:10.1371/journal.pone.0267866.
Denning DW, Kneale M, Sobel JD, Rautemaa-RichardsonR. Global burden of recurrent vulvovaginal candidiasis: asystematic review. Lancet Infect Dis. 2018;18(11):e339-e347.doi:10.1016/S1473-3099(18)30103-8.
Kennedy MA, Sobel JD. Vulvovaginal candidiasis causedby non-albicans Candida species: new insights. Curr InfectDis Rep. 2010;12(6):465-470. doi:10.1007/s11908-010-0137-9.
Sobel JD. Vulvovaginal candidosis. Lancet. 2007;369(9577):1961-1971. doi:10.1016/S0140-6736(07)60917-9.
Eckert LO. Acute vulvovaginitis. N Engl J Med. 2006;355(12):1244-1252. doi:10.1056/NEJMcp053251.
Chassot F, Negri M, Svidzinski TIE, Kioshima ES, SvidzinskiAE. Validation of risk factors in the diagnosis of vulvovaginalcandidiasis. Rev Inst Med Trop Sao Paulo. 2010;52(3):137-143. doi:10.1590/S0036-46652010000300003.
Sobel JD. Recurrent vulvovaginal candidiasis. AmJ Obstet Gynecol. 2016;214(1):15-21. doi:10.1016/j.ajog.2015.06.067.
Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr,Calandra TF, Edwards JE Jr, et al. Clinical practice guidelinesfor the management of candidiasis: 2009 update bythe Infectious Diseases Society of America. Clin InfectDis. 2009;48(5):503-535. doi:10.1086/596757.
Instituto Mexicano del Seguro Social. Guía de referenciarápida: diagnóstico y tratamiento de candidosis vulvovaginalen mujeres mayores de 12 años de edad [Internet].México: Instituto Mexicano del Seguro Social; 2020 [citado2025 Mar 11]. Disponible en: https://imss.gob.mx/sites/all/statics/guiasclinicas/609GRR.pdf
Hobbs MM, Sena AC. Modern diagnosis of Trichomonasvaginalis infection. Sex Transm Infect. 2013;89(6):434-438. doi:10.1136/sextrans-2013-051057.
Sánchez JT. Parasitología médica. 1a ed. Ciudad de México:Méndez Editores; 2022.
Rowley J, Vander Hoorn S, Korenromp E, Low N, UnemoM, Abu-Raddad LJ, et al. Chlamydia, gonorrhoea, trichomoniasisand syphilis: global prevalence and incidence estimates,2016. Bull World Health Organ. 2019;97(8):548-562. doi:10.2471/BLT.18.228486.
World Health Organization. Trichomoniasis [Internet].2024 Nov 25 [citado 2025 Mar 11]. Disponible en: https://www.who.int/news-room/fact-sheets/detail/trichomoniasis
Van der Pol B. Trichomonas vaginalis infection: the mostprevalent nonviral sexually transmitted infection receivesthe least public health attention. Clin Infect Dis. 2007;44(1):23-25. doi:10.1086/509925.
Meites E, Gaydos CA, Hobbs MM, Kissinger P, NyirjesyP, Schwebke JR, et al. A review of evidence-based care ofsymptomatic trichomoniasis and asymptomatic Trichomonasvaginalis infections. Clin Infect Dis. 2015;61(Suppl8):S837-S848. doi:10.1093/cid/civ738.
Kissinger P. Trichomonas vaginalis: a review of epidemiologic,clinical and treatment issues. BMC Infect Dis.2015;15:307. doi:10.1186/s12879-015-1055-0.
Sutton M, Sternberg M, Koumans EH, McQuillan G,Berman S, Markowitz L. The prevalence of Trichomonasvaginalis infection among reproductive-age women in theUnited States, 2001-2004. Clin Infect Dis. 2007;45(10):1319-1326. doi:10.1086/522532.
Sobel JD. Trichomoniasis. In: Holmes KK, Mårdh PA,Sparling PF, Wiesner PJ, editors. Sexually transmitteddiseases. 4th ed. New York (NY): McGraw-Hill; 2008.p. 825-844.
Swygard H, Sena AC, Hobbs MM, Cohen MS. Trichomoniasis:clinical manifestations, diagnosis and management.Sex Transm Infect. 2004;80(2):91-95. doi:10.1136/sti.2003.005124.
Huppert JS. Trichomoniasis in teens: an update. CurrOpin Obstet Gynecol. 2009;21(5):371-378. doi:10.1097/GCO.0b013e3283303b60.
Instituto Mexicano del Seguro Social. Guía de referenciarápida: diagnóstico y tratamiento de vaginitis infecciosa enmujeres en edad reproductiva en el primer nivel de atención[Internet]. México: Instituto Mexicano del Seguro Social;2020 [citado 2025 Mar 11]. Disponible en: https://imss.gob.mx/sites/all/statics/guiasclinicas/081GER.pdf