medigraphic.com
Órgano oficial de la Sociedad Mexicana de Cirugía Dermatológica y Oncológica, AC

2026, Number 1

<< Back Next >>

Dermatología Cosmética, Médica y Quirúrgica 2026; 24 (1)

Initial presentation compatible with bullous pemphigoid with subsequent Brunsting–Perry–type scalp involvement

Rodríguez-Vásquez JE, Ramírez-Cueto DA, Bazan-Alvarez VM, Arzapalo-Benavides JL

Language: Spanish
References: 9
Page: 51-55
PDF size: 287.49 Kb.


ABSTRACT

Brunsting–Perry pemphigoid (BPP) is a rare autoimmune blistering disease, described as a localized variant within the bullous pemphigoid spectrum, with the potential to cause irreversible scarring alopecia when the scalp is involved. We report the case of a 68-year-old man with multiple comorbidities who initially presented with clinical features compatible with bullous pemphigoid affecting the lower extremities and trunk, followed by exclusive scalp involvement showing a Brunsting–Perry phenotype, resulting in scarring alopecia. Diagnosis was established through clinicopathologic correlation and direct immunofluorescence. Treatment with systemic prednisone and doxycycline achieved clinical control, although relapses occurred during steroid tapering. This case highlights the importance of recognizing atypical and localized pemphigoid phenotypes and implementing individualized therapy to prevent irreversible sequelae.


REFERENCES

  1. Aromolo IF, Maronese CA, Moltrasio C, Genovese G, Marzano AV.Brunsting–Perry pemphigoid: a systematic review. Int JDermatol. 2022;61(11):1353–1358. Disponible en: https://doi.org/10.1111/ijd.16045.

  2. Ajiz PVA, Orellana AÁR, Pulido DN, Quintal M. Alopeciacicatricial secundaria a pénfigoide variedad Brunsting–Perry:reporte de un caso. Dermatol Cosmet Med Quir. 2019;17(2):128–130.

  3. Eichhoff G. Brunsting–Perry pemphigoid as a differential diagnosisof nonmelanoma skin cancer. Cureus. 2019;11(8):e5400.Disponible en: https://doi.org/10.7759/cureus.5400.

  4. Reis Gavazzoni Días MF, Aparecida Guedes Vilar E, de OliveiraBento C, Barreto Ibanez R, Falci Loures A, Barreto OliveiraCampos M, et al. Brunsting–Perry type pemphigoid causingsecondary cicatricial alopecia in 2 patients. Skin AppendageDisord. 2018;4(4):308–311. Disponible en: https://doi.org/10.1159/000485570.

  5. Zhou S, Zou Y, Pan M. Brunsting–Perry pemphigoid transitioningfrom previous bullous pemphigoid. JAAD Case Rep.2020;6(3):192–194. Disponible en: https://doi.org/doi:10.1016/j.jdcr.2019.12.018.

  6. Raef HS, Elmariah SB. Successful treatment of Brunsting–Perry cicatricial pemphigoid with dupilumab. J Drugs Dermatol.2021;20(10):1113–1115. Disponible en: https://doi.org/10.36849/JDD.6032.

  7. Niknezhad N, Golchin N, Hasanzadeh S, Ghalamkarpour F. Arare case of cicatricial pemphigoid confined to the scalp withassociated photodamage. Clin Case Rep. 2024;12(8):e9281.Disponible en: https://doi.org/10.1002/ccr3.9281.

  8. Imstepf V, Cazzaniga S, Beltraminelli H, Borradori L, Feldmeyer L.Brunsting–Perry pemphigoid: a retrospective case series ofa frequently unrecognized condition. J Am Acad Dermatol.2021;85(5):1324–1326. Disponible en: https://doi.org/10.1016/j.jaad.2020.10.029.

  9. Dagdug-Villegas AG, Guevara-Hernández C, Sanabria-Deseuza JA, Arellano-Mendoza MI, Mercadillo-Pérez P.Pénfigoide de Brunsting–Perry. Dermatol Rev Mex. 2021;65(Suppl 1):S107–S113. Disponible en: https://doi.org/10.24245/dermatolrevmex.v65id.5431.




2020     |     www.medigraphic.com