Ramírez HYL, Montes BJJ, Molinar L, Jorge DL, de la Garza HH

Language: Spanish
References: 9
Page: 134-138
PDF size: 425.27 Kb.

ABSTRACT

Background Hyaluronic acid has been more used since 1996, as it is considered a safe method to give volume and deal with defective tissue, that meets the requirements of biocompatibility, ease of application, long-lasting results, safety and cost-effectiveness. There are two types of hyaluronic acid: the two-phase and single-phase, developed by different companies.
Objective To determine the histopathological findings in the skin of Egyptian rats following application of monophasic versus biphasic hyaluronic acid at 15 and 30 days.
Material and method An experimental study was performed. We applied mono and biphasic intradermal hyaluronic acid on the back of Egyptian rat. Biopsies were taken at 15 to 30 days. Subsequently, a histopathological study of each one of the samples was made to determine the tissue reaction.
Results There were not rats that underwent significant changes with monophasic hyaluronic acid at 15 days, while one showed chronic inflammation at 30 days. With biphasic hyaluronic acid a rat showed reaction to foreign body to 15 days, and three rats had chronic inflammatory and granulomas at 30 days.
Conclusions Rats have a great response to foreign body forming granulomas and chronic inflammatory tissue with biphasic hyaluronic acid at 30 days.

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