Millán-Sánchez CA, Bocanegra-Kanagusico A, Sánchez-Narváez F

Language: Spanish
References: 13
Page: 43-50
PDF size: 339.24 Kb.

ABSTRACT

Introduction: breast cancer is an increasingly common condition among women in both developed and developing countries; annually, it causes hundreds of thousands of deaths worldwide. In addition to mammogram and ultrasound, magnetic resonance has proved useful in studying malignant breast disorders; however, at times it can be a formidable challenge to distinguish malignant from benign lesions. Measuring choline by magnetic resonance with spectroscopy offers the capacity to increase the possibility for differentiation.
Objetive: determine the correlation between concentrations of choline and the histological strain found in breast biopsies.
Material and Methods: a transverse, observational, and descriptive study in the period October 2015 to June 2016. We analyzed data from 47 patients with BIRADS 4a, 4b, 4c, and 5, associating concentrations of choline by magnetic resonance with spectroscopy with the histopathological results of breast biopsies at Hospital General Naval de Alta Especialidad.
Results: of the 47 patients who satisfied all the inclusion criteria, there were 46 women (97.9%) and 1 man (2.1%). In the pathology (biopsy) results, 21 (44.7%) were benign and 26 (55.3%) malignant. We obtained a high correlation between concentrations of choline and malignant lesions.
Conclusions: using a cutoff point in choline concentration of 59.5 mmol/L, we achieved 92.3% sensitivity and up to 100% specificity; positive predictive value of 100% and negative of 91.3%. These results are comparable with other studies which report up to 100% sensitivity with specificity also at 100%. Like other investigations, in this study we succeeded in showing that magnetic resonance with spectroscopy can be used effectively in non-invasive evaluation of malignant tumors, and in differentiation between benign or malignant conditions with a high degree of precision.

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